We receive compensation from the providers of the services and products featured on this website. This impacts the offers’ positioning, rating & scoring. Advertising Disclosure


Syphilis Symptoms for Every Stage of Syphilis

The information provided herein does not constitute an expert or medical advice, nor intended to replace such advice.

Sexual Health

Syphilis symptoms aren’t always easy to spot because the signs can be so subtle, the first stage of syphilis, which is also known as the primary stage may present as a painless sore, also known as a chancre.

Before we dive in, let’s do a little recap on syphilis.

Syphilis is a bacterial sexually transmitted infection caused by bacteria treponema pallidum. It is most commonly spread through sexual contact.

Syphilis is often known as “The Great Pretender” because the symptoms can mimic or seem like another health condition.

Syphilis is common in the United States, in fact, in the last number of years, it has been shown that syphilis continues to be on the rise. Cases of primary and secondary syphilis increased by 11.2% between 2018-2019.

Want some more background information before diving into the symptoms? Read: What is syphilis?

Let’s get down to it and dive into syphilis symptoms and what you should be looking out for if you are concerned that you have syphilis.

**Syphilis symptoms **

Syphilis symptoms tend to be the same in men and women, in that the symptoms of syphilis usually present in the same way.

The symptoms you experience will depend on the stage of syphilis you are experiencing.

Syphilis is broken into four stages:

  1. Primary
  2. Secondary
  3. Latent
  4. Tertiary stages.

Article image

Symptoms of primary syphilis

The symptoms of primary syphilis may include the development of a painless sore, also known as a chancre. Chancres are usually round in shape and firm to the touch.

In men, the chancre is most likely to develop on the head or shaft of the penis. In women, the chancre is most likely to develop on the vulva, vagina or cervix.

Chancres may also appear on the anus, buttocks or upper thighs.

Usually the symptoms of syphilis will develop 10 days to 3 months following infection. The average onset of symptoms is 21 days.

Symptoms of primary syphilis will go away on their own if they are not treated, however this does not mean that you no longer have syphilis, it means that primary syphilis will develop to secondary syphilis.

Article image

**Symptoms of secondary syphilis **

The symptoms of secondary syphilis may coincide with the healing process of primary syphilis. The first sign of secondary syphilis is the development of a reddish-brown rash which may cover a number of different body parts. It most commonly begins on the hands and feet. The rash may be slightly raised.

The rash is not always easy to notice, usually it doesn’t itch sometimes it can be faint in colour.

Some other symptoms of secondary syphilis include:

  • Unexplained tiredness
  • Headaches
  • Fever
  • Hair loss
  • Muscle pain
  • A sore throat
  • Swollen lymph nodes

**Symptoms of latent syphilis **

Latent syphilis refers to the 12 month period following initial infection.

During latent syphilis, there are no symptoms, which means that it can continue to go undetected. Untreated syphilis in the latent stage can last anywhere between 3 and 30 years.

If you do not receive treatment during this stage, your syphilis will progress to the tertiary stage.

**Symptoms of tertiary syphilis **

The symptoms of tertiary syphilis vary from person to person. During the tertiary stage, the bacteria have multiplied in one or more organs in the body. This means that the brain, nerves, eyes, heart, blood vessels, liver, bones and joints could be affected.

Some conditions that may arise from tertiary syphilis include neurosyphilis, cardiovascular syphilis and gummatous syphilis.


What is one of the first signs of syphilis?

A painless sore known as a chancre is usually the first sign of syphilis. This sore may develop on the head or shaft of the penis in men and the vagina, vulva and cervix of women.

The chancre may also develop on the buttocks, anus or upper thighs of both men and women.

How long can you have syphilis without knowing?

You could have syphilis for up to 30 years without realizing given that the symptoms can be so subtle. This is why it is so important to ensure that you attend regular sexual health screenings.

The symptoms of syphilis usually present in primary or secondary syphilis but as we have outlined, these symptoms can be difficult to spot.

Read: What is the best at home STD test?

What are the symptoms of late stage syphilis?

The symptoms of later stage syphilis may not be present. In the latent stage, there are no symptoms as the bacteria continues to multiply. In tertiary syphilis, a new health complication may arise due to the fact that it was not treated earlier.

These conditions may affect the brain, nerves, eyes, heart, blood vessels, liver, bones and joints

Can you get syphilis without being sexually active?

You can get syphilis without having sex. Coming into close contact with an infected person’s genital, mouth or rectum could lead you to contracting syphilis.

Written by Hannah Kingston on May 3, 2021


Hannah Kingston

Hannah Kingston

Dec 11, 2022

More from Syphilis

How Does a Syphilis Test Work?
How does a syphilis test work? Here’s everything you need to know about syphilis screening both at home and in a clinic.
Updated at Jan 22, 2023

Hannah Kingston

Sexual Health
3 min read

What is Syphilis?
What is syphilis? We talk you through everything you need to know including the first sign of syphilis, what syphilis looks like and some more of the most frequently asked questions about syphilis.
Updated at Jan 19, 2023

Hannah Kingston

Sexual Health
3 min read

Can syphilis affect the nose?
Syphilis is a relatively common STI, but can syphilis affect the nose? STDWatch provides a comprehensive guide on nasal syphilis and its manifestations.
Updated at Jan 19, 2023

Dr. Andrea Pinto Lopez

Sexual Health
3 min read

You may also like

10 panel STD tests
Choose the right 10 panel STD tests for you in the most private, safe and affordable way possible
Updated at Oct 25, 2023

Hannah Kingston

Sexual Health
STD Tests
3 min read

Can I have an STD without knowing it?
You can have without knowing it. One of the reasons many people don't know they're infected is that many STDs don't have any symptoms.
Updated at Feb 06, 2023

Tommy Gonzales

Sexual Health
STD Symptoms
3 min read

How Do I Know Which STD Test I Need?
There are many STDs known today, making it sometimes confusing to know which test you should get and when.
Updated at Feb 06, 2023

Tommy Gonzales

Sexual Health
STD Tests
3 min read

Top 3 STD Testing Services
Most Popular


    • Confidential results in 2-5 days
    • Free & discreet shipping - both ways
    • Uses hospitals labs for max accuracy
    • Medical support available 24/7
    • Consultation for treatment options
    • FSA & HSA cards accepted
    • FDA listed tests